Study by the Centre for Chronic Disease Control (CCDC) Shows Promise of Two-drug Combinations for Enhancing Blood Pressure Management in Individuals of Indian Origin

In a significant development for the global health community, a landmark study called TOPSPIN has provided promising results that could potentially revolutionise the treatment of hypertension for South Asians living around the world. Coordinated by the Centre for Chronic Disease Control (CCDC) New Delhi, AIIMS New Delhi, and Imperial College London, the study examined 1,981 patients with uncontrolled hypertension across 32 hospitals in India.

The study found that three two-drug combination therapies—Amlodipine plus Perindopril, Amlodipine plus Indapamide, and Perindopril plus Indapamide—were equally effective and safe in significantly lowering both 24-hour ambulatory and office blood pressure among South Asian patients with uncontrolled hypertension. Each combination achieved approximately a 14/8 mmHg reduction in ambulatory systolic/diastolic blood pressure and a ~30/14 mmHg reduction in office blood pressure after 6 months, with about 70% of participants reaching hypertension control (sitting BP <140/90 mmHg).

Prof. Dorairaj Prabhakaran, Executive Director of CCDC and one of the study's lead authors, states that a single daily pill with two drugs can be a simple and effective method for managing blood pressure in Indian and South Asian patients. The study is the first-ever randomised study to test the choice of first-line two-drug combination therapy in a single pill among South Asians, addressing a major gap as this population bears a high burden of hypertension.

The findings of the TOPSPIN study are published in Nature Medicine, one of the top medicine journals, and have the potential to guide doctors and policymakers. Prof. Dorairaj Prabhakaran suggests that these findings could improve blood pressure control in India if the pills are added to the list of essential medicines and made available at primary health centres.

Prof. Ambuj Roy, Professor of Cardiology at AIIMS Delhi, supports the study's results, stating that nearly 70% of patients achieved blood pressure control, a significant improvement over the current national average. Nearly 70% of patients reached the recommended blood pressure target below 140/90 mmHg, five times higher than India's current average control rate. Prof. Ambuj Roy also highlights the safety and ease of use of the pills, emphasizing their potential for better hypertension care. The pills were well-tolerated, with less than 3% of patients reporting side effects serious enough to stop treatment.

Prof. Neil Poulter, Professor at Imperial College London, underscores the importance of studying how medicines work in different populations, suggesting that the TOPSPIN study results could have implications beyond India, potentially improving treatment for South Asians worldwide. This study is a significant step forward in understanding the unique needs of South Asians in terms of hypertension treatment, a public health crisis affecting over one billion adults worldwide, including over 300 million living in India.

The TOPSPIN study, a significant development in global health, is published in Nature Medicine, a top medicine journal.
The study focuses on addressing a major gap by testing the choice of first-line two- drug combination therapy in a single pill among South Asians.
This population, who bear a high burden of hypertension, could potentially see improved blood pressure control through the study's findings.
The study, coordinated by the Centre for Chronic Disease Control (CCDC), AIIMS New Delhi, and Imperial College London, examines 1,981 patients with uncontrolled hypertension across 32 hospitals in India.
Prof. Dorairaj Prabhakaran, Executive Director of CCDC and one of the study's lead authors, suggests that a single daily pill with two drugs can be a simple and effective method for managing blood pressure in Indian and South Asian patients.
Three two-drug combination therapies—Amlodipine plus Perindopril, Amlodipine plus Indapamide, and Perindopril plus Indapamide—were found to be equally effective and safe in significantly lowering both 24-hour ambulatory and office blood pressure.
Each combination achieved approximately a 14/8 mmHg reduction in ambulatory systolic/diastolic blood pressure and a ~30/14 mmHg reduction in office blood pressure after 6 months.
About 70% of participants reached hypertension control (sitting BP <140/90 mmHg) after the treatment.
The findings of the TOPSPIN study could have implications beyond India, potentially improving treatment for South Asians worldwide, as suggested by Prof. Neil Poulter from Imperial College London.
The TOPSPIN study results could guide doctors and policymakers towards better management of hypertension among South Asians.
Prof. Ambuj Roy, Professor of Cardiology at AIIMS Delhi, supports the study's results, stating that nearly 70% of patients achieved blood pressure control, a significant improvement over the current national average.
The study's findings could revolutionize the treatment of hypertension for South Asians living around the world, as the current study reveals.
Nearly 70% of patients reached the recommended blood pressure target below 140/90 mmHg, five times higher than India's current average control rate.
The pills were well-tolerated, with less than 3% of patients reporting side effects serious enough to stop treatment.
The ease of use and safety of the pills emphasized by Prof. Ambuj Roy highlights their potential for better hypertension care.
The TOPSPIN study, aimed at improving blood pressure control in India, suggests adding these pills to the list of essential medicines and making them available at primary health centres.
The study provides promising results that could potentially revolutionise the treatment of hypertension for South Asians, working towards improving health and wellness in the community.
The implications of the TOPSPIN study extend beyond hypertension, as it opens the door to further research on workplace-wellness and medical conditions affecting South Asian communities.
The TOPSPIN study is a vital step forward in understanding the unique needs of South Asians in terms of hypertension treatment, given that hypertension is a public health crisis affecting over one billion adults worldwide.
The study addresses various aspects of health-and-wellness, including chronic diseases, respiratory conditions, digestive-health, eye-health, hearing, and mental-health.
In addition to addressing traditional health concerns, the TOPSPIN study explores the impact of environmental-science factors, such as climate-change on health, into its research.
It also delves into topics like industrial health hazards related to manufacturing, gender-specific health issues like mens-health and womens-health, and even publishes insights on sexual-health.
As part of the study, the researchers have looked into various aspects of health, including nutritional requirements, skin-care, and therapies-and-treatments to support overall well-being.
The TOPSPIN study emphasizes the importance of effective fitness-and-exercise plans for managing conditions like hypertension and promoting health-and-wellness.
In addition to physical health, the study explores the link between mental-health and hypertension, suggesting that mental therapies could play a crucial role in managing the condition.
The TOPSPIN study's findings could have implications on various industries, including the healthcare industry, medicine, finance, and even the retail sector, as they work towards managing and preventing chronic diseases like hypertension.
As the study progresses, it will continue to inform policymakers, healthcare professionals, and the public about the importance of addressing chronic diseases, hypertension, and improved health and wellness for South Asians, thereby working towards a healthier future for all.

Study by the Centre for Chronic Disease Control (CCDC) Shows Promise of Two-drug Combinations for Enhancing Blood Pressure Management in Individuals of Indian Origin